PRDX6

PRDX6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRDX6, 1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29, peroxiredoxin 6
External IDsMGI: 894320 HomoloGene: 3606 GeneCards: PRDX6
EC number1.11.1.9
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q25.1Start173,477,266 bp[1]
End173,488,807 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9588

11758

Ensembl

ENSG00000117592

ENSMUSG00000026701

UniProt

P30041

O08709

RefSeq (mRNA)

NM_004905

NM_001303408
NM_007453

RefSeq (protein)

NP_004896

NP_001290337
NP_031479

Location (UCSC)Chr 1: 173.48 – 173.49 MbChr 1: 161.24 – 161.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes.

Function

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.[6]

Model organisms

Model organisms have been used in the study of PRDX6 function. A conditional knockout mouse line, called Prdx6tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117592 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026701 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Phelan SA (Mar 2001). "AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant". Antioxid Redox Signal. 1 (4): 571–84. PMID 11233154.
  6. 1 2 "Entrez Gene: PRDX6 peroxiredoxin 6".
  7. ↑ "Salmonella infection data for Prdx6". Wellcome Trust Sanger Institute.
  8. ↑ "Citrobacter infection data for Prdx6". Wellcome Trust Sanger Institute.
  9. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  10. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ↑ "International Knockout Mouse Consortium".
  12. ↑ "Mouse Genome Informatics".
  13. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  16. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Manevich Y, Fisher AB (2005). "Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism". Free Radic. Biol. Med. 38 (11): 1422–32. doi:10.1016/j.freeradbiomed.2005.02.011. PMID 15890616.
  • Akesson B; Gustavii, B (1975). "Work in progress. Occurrence of phospholipase A1 and A2 in human decidua". Prostaglandins. 9 (5): 667–73. doi:10.1016/0090-6980(75)90106-9. PMID 240188.
  • Hochstrasser DF; Frutiger S; Paquet N; et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Yeats DA, Bakhle YS (1989). "Phospholipases A2 and C of human lung; subcellular distribution and substrate selectivity". Biochim. Biophys. Acta. 1003 (2): 189–95. doi:10.1016/0005-2760(89)90254-3. PMID 2730891.
  • Nagase T; Miyajima N; Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  • Golaz O; Hughes GJ; Frutiger S; et al. (1994). "Plasma and red blood cell protein maps: update 1993". Electrophoresis. 14 (11): 1223–31. doi:10.1002/elps.11501401183. PMID 8313871.
  • Kim TS; Sundaresh CS; Feinstein SI; et al. (1997). "Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein". J. Biol. Chem. 272 (4): 2542–50. doi:10.1074/jbc.272.4.2542. PMID 8999971.
  • Frank S, Munz B, Werner S (1997). "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene". Oncogene. 14 (8): 915–21. doi:10.1038/sj.onc.1200905. PMID 9050990.
  • Kang SW, Baines IC, Rhee SG (1998). "Characterization of a mammalian peroxiredoxin that contains one conserved cysteine". J. Biol. Chem. 273 (11): 6303–11. doi:10.1074/jbc.273.11.6303. PMID 9497358.
  • Choi HJ; Kang SW; Yang CH; et al. (1998). "Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution". Nat. Struct. Biol. 5 (5): 400–6. doi:10.1038/nsb0598-400. PMID 9587003.
  • Chen JW; Dodia C; Feinstein SI; et al. (2000). "1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities". J. Biol. Chem. 275 (37): 28421–7. doi:10.1074/jbc.M005073200. PMID 10893423.
  • Fatma N, Singh DP, Shinohara T, Chylack LT (2002). "Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress". J. Biol. Chem. 276 (52): 48899–907. doi:10.1074/jbc.M100733200. PMID 11677226.
  • Wagner E; Luche S; Penna L; et al. (2002). "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress". Biochem. J. 366 (Pt 3): 777–85. doi:10.1042/BJ20020525. PMC 1222825. PMID 12059788.
  • Leavey PJ; Gonzalez-Aller C; Thurman G; et al. (2003). "A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity". J. Biol. Chem. 277 (47): 45181–7. doi:10.1074/jbc.M202869200. PMID 12121978.
  • Manevich Y; Sweitzer T; Pak JH; et al. (2002). "1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11599–604. doi:10.1073/pnas.182384499. PMC 129315. PMID 12193653.
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Krapfenbauer K; Engidawork E; Cairns N; et al. (2003). "Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders". Brain Res. 967 (1–2): 152–60. doi:10.1016/S0006-8993(02)04243-9. PMID 12650976.
  • Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, Kreuchwig F, Vrbacky M, Balas L, Durand T, Hübner N, Fisher AB, Kopecky J, Pravenec M (Jun 2018). "Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid (9-PAHSA)". Diabetes. 67 (6): 1190–1199. doi:10.2337/db17-1087. PMID 29549163.
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