O-sialoglycoprotein endopeptidase
| O-sialoglycoprotein endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.57 | ||||||||
| CAS number | 129430-53-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
O-sialoglycoprotein endopeptidase (EC 3.4.24.57, glycoprotease, glycophorin A proteinase, glycoproteinase, sialoglycoprotease, sialoglycoproteinase, "OSGE") is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
This enzyme is secreted by the bacterium Pasteurella haemolytica.
References
- ↑ Abdullah, K.M.; Lo, R.Y.C.; Mellors, A. (1991). "Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene". J. Bacteriol. 173: 5597–5603. doi:10.1128/jb.173.18.5597-5603.1991. PMC 208286. PMID 1885539.
- ↑ Abdullah, K.M.; Udoh, E.A.; Shewen, P.E.; Mellors, A. (1992). "A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins". Infect. Immun. 60: 56–62. PMC 257502. PMID 1729196.
- ↑ Sutherland, D.R.; Abdullah, K.M.; Cyopick, P.; Mellors, A. (1992). "Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica". J. Immunol. 148: 1458–1464. PMID 1371528.
External links
- O-sialoglycoprotein+endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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