O-phospho-L-seryl-tRNA:Cys-tRNA synthase

O-phospho-L-seryl-tRNA:Cys-tRNA synthase
Identifiers
EC number 2.5.1.73
CAS number 1239229-21-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

O-phospho-L-seryl-tRNA:Cys-tRNA synthase (EC 2.5.1.73, SepCysS, Sep-tRNA:Cys-tRNA synthase) is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase.[1][2][3] This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNACys + sulfide L-cysteinyl-tRNACys + phosphate

References

  1. Fukunaga, R.; Yokoyama, S. (2007). "Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus". J. Mol. Biol. 370 (1): 128–141. doi:10.1016/j.jmb.2007.04.050. PMID 17512006.
  2. Hauenstein, S.I.; Perona, J.J. (2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". J. Biol. Chem. 283 (32): 22007–22017. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
  3. Yuan, J.; Palioura, S.; Salazar, J.C.; Su, D.; O'Donoghue, P.; Hohn, M.J.; Cardoso, A.M.; Whitman, W.B.; Soll, D. (2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. USA. 103 (50): 18923–18927. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
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