N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase

N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Identifiers
EC number 2.4.1.289
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289, WbbL) is an enzyme with systematic name dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

This enzyme requires Mn2+ or Mg2+.

References

  1. ↑ Mills, J.A.; Motichka, K.; Jucker, M.; Wu, H.P.; Uhlik, B.C.; Stern, R.J.; Scherman, M.S.; Vissa, V.D.; Pan, F.; Kundu, M.; Ma, Y.F.; McNeil, M. (2004). "Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability". J. Biol. Chem. 279 (42): 43540–43546. doi:10.1074/jbc.M407782200. PMID 15294902.
  2. ↑ Grzegorzewicz, A.E.; Ma, Y.; Jones, V.; Crick, D.; Liav, A.; McNeil, M.R. (2008). "Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL". Microbiology. 154 (Pt 12): 3724–3730. doi:10.1099/mic.0.2008/023366-0. PMC 2717732. PMID 19047740.
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