N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Identifiers
EC number 2.8.2.33
CAS number 242469-38-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.[1][2] This enzyme catalyses the following chemical reaction

(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
(2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

The enzyme is activated by divalent cations and reduced glutathione.

References

  1. ↑ Ito, Y.; Habuchi, O. (2000). "Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage". J. Biol. Chem. 275 (44): 34728–34736. doi:10.1074/jbc.M909633199. PMID 10871629.
  2. ↑ Ohtake, S.; Ito, Y.; Fukuta, M.; Habuchi, O. (2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". J. Biol. Chem. 276: 43894–43900. doi:10.1074/jbc.M104922200. PMID 11572857.
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