Mannan-binding lectin-associated serine protease-2

Mannan-binding lectin-associated serine protease-2
Identifiers
EC number 3.4.21.104
CAS number 214915-16-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.

References

  1. ↑ Matsushita, M.; Fujita, T. (1992). "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease". J. Exp. Med. 176 (6): 1497–1502. doi:10.1084/jem.176.6.1497. PMC 2119445. PMID 1460414.
  2. ↑ Thiel, S.; Vorup-Jensen, T.; Stover, C.M.; Schwaeble, W.; Laursen, S.B.; Poulsen, K.; Willis, A.C.; Eggleton, P.; Hansen, S.; Holmskov, U.; Reid, K.B.; Jensenius, J.C. (1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature. 386 (6624): 506–510. doi:10.1038/386506a0. PMID 9087411.
  3. ↑ Rossi, V.; Cseh, S.; Bally, I.; Thielens, N.M.; Jensenius, J.C.; Arlaud, G.J. (2001). "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2". J. Biol. Chem. 276 (44): 40880–40887. doi:10.1074/jbc.M105934200. PMID 11527969.
  4. ↑ Ambrus, G.; Gal, P.; Kojima, M.; Szilagyi, K.; Balczer, J.; Antal, J.; Graf, L.; Laich, A.; Moffatt, B.E.; Schwaeble, W.; Sim, R.B.; Zavodszky, P. (2003). "Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments". J. Immunol. 170 (3): 1374–1382. doi:10.4049/jimmunol.170.3.1374. PMID 12538697.
  5. ↑ Harmat, V.; Gal, P.; Kardos, J.; Szilagyi, K.; Ambrus, G.; Vegh, B.; Naray-Szabo, G.; Zavodszky, P. (2004). "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions". J. Mol. Biol. 342 (5): 1533–1546. doi:10.1016/j.jmb.2004.07.014. PMID 15364579.
  6. ↑ Chen, C.B.; Wallis, R. (2004). "Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases". J. Biol. Chem. 279 (25): 26058–26065. doi:10.1074/jbc.M401318200. PMID 15060079.
  7. ↑ Teillet, F.; Dublet, B.; Andrieu, J.P.; Gaboriaud, C.; Arlaud, G.J.; Thielens, N.M. (2005). "The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases". J. Immunol. 174 (5): 2870–2877. doi:10.4049/jimmunol.174.5.2870. PMID 15728497.
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