Magnolysin

Magnolysin
Identifiers
EC number 3.4.24.62
CAS number 162875-09-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Magnolysin (EC 3.4.24.62, bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-oxytocin/neurophysin convertase, prooxyphysin proteinase, pro-oxytocin convertase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-Ala-Val-.

This endopeptidase is present in bovine pituitary neurosecretory granules.

References

  1. ↑ Clamagirand C, Creminon C, Fahy C, Boussetta H, Cohen P (September 1987). "Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet". Biochemistry. 26 (19): 6018–23. doi:10.1021/bi00393a011. PMID 2825769.
  2. ↑ Créminon C, Rholam M, Boussetta H, Marrakchi N, Cohen P (May 1988). "Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme". Journal of Chromatography. 440: 439–48. doi:10.1016/s0021-9673(00)94547-3. PMID 3042797.
  3. ↑ Brakch N, Boussetta H, Rholam M, Cohen P (September 1989). "Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model". The Journal of Biological Chemistry. 264 (27): 15912–6. PMID 2674120.
  4. ↑ Plevrakis I, Clamagirand C, Créminon C, Brakch N, Rholam M, Cohen P (March 1989). "Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor". Biochemistry. 28 (6): 2705–10. doi:10.1021/bi00432a051. PMID 2659078.
  5. ↑ Guillou MD, Camier M, Clamagirand C (August 1994). "Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary". The Journal of Endocrinology. 142 (2): 345–52. doi:10.1677/joe.0.1420345. PMID 7931007.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.