Magnesium protoporphyrin IX methyltransferase
| magnesium protoporphyrin IX methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.11 | ||||||||
| CAS number | 9029-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a magnesium protoporphyrin IX methyltransferase (EC 2.1.1.11) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + magnesium protoporphyrin IX S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester
Thus, the two substrates of this enzyme are S-adenosyl methionine and magnesium protoporphyrin IX, whereas its two products are S-adenosylhomocysteine and magnesium protoporphyrin IX 13-methyl ester.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.
References
- GIBSON KD, NEUBERGER A, TAIT GH (1963). "STUDIES ON THE BIOSYNTHESIS OF PORPHYRIN AND BACTERIOCHLOROPHYLL BY RHODOPSEUDOMONAS SPHEROIDES. 4. S-ADENOSYLMETHIONINEMAGNESIUM PROTOPORPHYRIN METHYLTRANSFERASE". Biochem. J. 88: 325&ndash, 34. PMC 1202116. PMID 14063871.
- Shepherd M, Reid JD, Hunter CN (2003). "Purification and kinetic characterization of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803". Biochem. J. 371 (Pt 2): 351&ndash, 60. doi:10.1042/BJ20021394. PMC 1223276. PMID 12489983.
- Bollivar DW, Jiang ZY, Bauer CE, Beale SI (1994). "Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase". J. Bacteriol. 176 (17): 5290&ndash, 6. PMC 196713. PMID 8071204.
- Gibson LC, Hunter CN (1994). "The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methyltransferase". FEBS Lett. 352 (2): 127&ndash, 30. doi:10.1016/0014-5793(94)00934-1. PMID 7925960.
- Ebbon JG, Tait GH (1969). "Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z". Biochem. J. 111 (4): 573&ndash, 82. PMC 1187578. PMID 5774480.
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