Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase

Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
Identifiers
EC number 1.14.13.81
CAS number 92353-62-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase (EC 1.14.13.81, Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase) is an enzyme with systematic name magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating) .[1] This enzyme catalyses the following chemical reaction

magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 divinylprotochlorophyllide + 3 NADP+ + 5 H2O (overall reaction)
(1a) magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O
(1b) 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O
(1c) 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 divinylprotochlorophyllide + NADP+ + 2 H2O

This enzyme requires Fe(II) for activity.

References

  1. ↑ Bollivar, D.W.; Beale, S.I. (1996). "The chlorophyll biosynthetic enzyme Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase (characterization and partial purification from Chlamydomonas reinhardtii and Synechocystis sp. PCC 6803)". Plant Physiol. 112 (1): 105–114. doi:10.1104/pp.112.1.105. PMC 157929. PMID 12226378.
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