MAP2K5

MAP2K5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NPT, 2O2V, 4IC7
Identifiers
Aliases	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
External IDs	MGI: 1346345 HomoloGene: 115933 GeneCards: MAP2K5
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 67,542,709 bp[1] End 67,807,123 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B-C Start 63,163,768 bp[2] End 63,377,902 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • protein serine/threonine kinase activity • MAP kinase kinase activity Cellular component • cytoplasm • cytosol • spindle • cell nucleus • intracellular Biological process • negative regulation of chemokine (C-X-C motif) ligand 2 production • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • phosphorylation • positive regulation of epithelial cell proliferation • cellular response to laminar fluid shear stress • cellular response to growth factor stimulus • negative regulation of transcription from RNA polymerase II promoter • negative regulation of interleukin-8 biosynthetic process • positive regulation of protein metabolic process • negative regulation of response to cytokine stimulus • MAPK cascade • ERK5 cascade • negative regulation of cell migration involved in sprouting angiogenesis • protein phosphorylation • heart development • positive regulation of cell growth • activation of MAPK activity • peptidyl-tyrosine phosphorylation • negative regulation of heterotypic cell-cell adhesion • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of NF-kappaB transcription factor activity • signal transduction • positive regulation of transcription from RNA polymerase II promoter • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5607	23938
Ensembl	ENSG00000137764	ENSMUSG00000058444
UniProt	Q13163	Q9WVS7
RefSeq (mRNA)	NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162	NM_011840 NM_001364492 NM_001364493 NM_001364494
RefSeq (protein)	NP_001193733 NP_002748 NP_660143	NP_035970 NP_001351421 NP_001351422 NP_001351423
Location (UCSC)	Chr 15: 67.54 – 67.81 Mb	Chr 9: 63.16 – 63.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.^[5][6]

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.^[6]

Upstream

This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream

This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions

MAP2K5 has been shown to interact with MAPK7,^[5] MAP3K2,^[7] Protein kinase Mζ^[8] and MAP3K3.^[7][9]

References

Further reading