BRSK2

BRSK2
Identifiers
AliasesBRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, BR serine/threonine kinase 2
External IDsMGI: 1923020 HomoloGene: 123829 GeneCards: BRSK2
EC number2.7.11.26
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start1,389,899 bp[1]
End1,462,689 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9024

75770

Ensembl

ENSG00000174672

ENSMUSG00000053046

UniProt

Q8IWQ3

Q69Z98

RefSeq (mRNA)

NM_001256627
NM_001256629
NM_001256630
NM_001282218
NM_003957

NM_001009929
NM_001009930
NM_001276763
NM_029426

RefSeq (protein)

NP_001243556
NP_001243558
NP_001243559
NP_001269147
NP_003948

NP_001009929
NP_001009930
NP_001263692
NP_083702

Location (UCSC)Chr 11: 1.39 – 1.46 MbChr 7: 141.95 – 142 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174672 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053046 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.
  6. ↑ Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.
  7. ↑ "Entrez Gene: BRSK2 BR serine/threonine kinase 2".

Further reading

  • Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
  • Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Lu R, Niida H, Nakanishi M (Jul 2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". The Journal of Biological Chemistry. 279 (30): 31164–70. doi:10.1074/jbc.M404728200. PMID 15150265.
  • Sabater L, Gómez-Choco M, Saiz A, Graus F (Dec 2005). "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis". Journal of Neuroimmunology. 170 (1–2): 186–90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222.
  • Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y (Apr 2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron. 50 (2): 261–75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837.
  • Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y, Yu L (Sep 2006). "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochemical and Biophysical Research Communications. 347 (4): 867–71. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.


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