EIF2AK4

EIF2AK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UKX, 4OTN
Identifiers
Aliases	EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDs	MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	40,035,591 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	118,475,234 bp[2]
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • tRNA binding; • kinase activity; • protein serine/threonine kinase activity; • RNA binding; • ATP binding; • eukaryotic translation initiation factor 2alpha kinase activity;
Cellular component	• cytoplasm; • polysome; • cytosolic ribosome;
Biological process	• positive regulation of translational initiation in response to starvation; • adaptive immune response; • negative regulation of neuron differentiation; • positive regulation of long-term synaptic potentiation; • positive regulation of adaptive immune response; • negative regulation of translational initiation in response to stress; • negative regulation of translational initiation; • phosphorylation; • immune system process; • cellular response to UV; • cellular response to amino acid starvation; • negative regulation of CREB transcription factor activity; • regulation of feeding behavior; • learning; • nervous system development; • viral translation; • neuron projection extension; • protein phosphorylation; • cellular response to cold; • long-term memory; • defense response to virus; • cellular response to leucine starvation; • cell cycle arrest; • regulation of eIF2 alpha phosphorylation by amino acid starvation; • eiF2alpha phosphorylation in response to endoplasmic reticulum stress; • induction by virus of host autophagy; • protein autophosphorylation; • cell cycle; • negative regulation by host of viral genome replication; • viral process; • regulation of translation; • regulation of translational initiation; • positive regulation of defense response to virus by host; • T cell activation involved in immune response; • DNA damage checkpoint; • regulation of translational initiation by eIF2 alpha phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	440275
	27103
	ENSG00000128829
	ENSMUSG00000005102
	Q9P2K8
	Q9QZ05
	NM_001013703
	NM_001177806; NM_013719; NM_001355383
	NP_001013725
	NP_001171277; NP_038747; NP_001342312
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.^[5]^[6]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
1 2 "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10504407-5] Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.

[entrez-6] 1 2 "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

EIF2AK4

See also

References

Further reading