| Nominee | Wins | Nominations |
|---|
| Quincy Jones [1] | 27 | 79 |
| Alison Krauss | 27 | 42 |
| Stevie Wonder | 25 | 74 |
| Vladimir Horowitz | 25 | 45 |
| John Williams | 23 | 67 |
| Chick Corea [2] | 22 | 64 |
| Beyoncé | 22 | 62 |
| Jay-Z | 21 | 74 |
| Kanye West | 21 | 68 |
| Vince Gill | 21 | 44 |
| Henry Mancini | 20 | 72 |
| Bruce Springsteen | 20 | 50 |
Pat Metheny [3]
Al Schmitt | 20 | 36 |
| Aretha Franklin | 18 | 44 |
| Tony Bennett | 18 | 34 |
| Yo-Yo Ma | 18 | 27 |
| Jimmy Sturr | 18 | 22 |
| Ray Charles | 17 | 37 |
| James Mallinson | 16 | 49 |
| Leonard Bernstein | 16 | 23 |
| Paul Simon | 16 | 35 |
| Eminem | 15 | 43 |
| Steven Epstein | 15 | 34 |
| Alicia Keys | 15 | 29 |
| David Frost | 15 | 19 |
| Bela Fleck | 14 | 33 |
| Phil Ramone | 14 | 32 |
| Alison Krauss and Union Station | 14 | 18 |
| Jay David Saks | 13 | 53 |
| Emmylou Harris | 13 | 47 |
| Michael Jackson | 13 | 38 |
| Robert Woods | 13 | 29 |
| Leontyne Price | 13 | 25 |
| Ella Fitzgerald | 13 | 20 |
| T Bone Burnett | 13 | 18 |
| Thomas Z Shepard | 12 | 50 |
| Dixie Chicks | 12 | 19 |
| Babyface | 11 | 49 |
| Pharrell Williams | 11 | 38 |
| Michael Tilson Thomas | 11 | 34 |
| Shirley Caesar | 11 | 28 |
| Bruno Mars | 11 | 27 |
| Al Green | 11 | 21 |
Arif Mardin
Roger Miller | 11 | 18 |
| Andre Previn | 10 | 44 |
Bob Dylan
Justin Timberlake | 10 | 38 |
Mary J. Blige
Sheryl Crow
Taylor Swift | 10 | 31 |
Chaka Khan
John Legend | 10 | 28 |
CeCe Winans
Foo Fighters | 10 | 27 |
Linda Ronstadt
Bonnie Raitt | 10 | 26 |
| Bobby McFerrin | 10 | 18 |
| Carlos Santana a.k.a Santana (band) | 10 | 14 |
| Pat Metheny Group | 10 | 13 |
| Frank Sinatra | 9 | 31 |
| Ringo Starr | 9 | 27 |
| Natalie Cole | 9 | 21 |
| Norah Jones | 9 | 16 |
| Hillary Scott | 9 | 15 |
| Emerson String Quartet | 9 | 13 |
| Willie Nelson | 8 | 49 |
| Dolly Parton | 8 | 47 |
| Barbra Streisand | 8 | 44 |
| Asleep At The Wheel | 8 | 27 |
| Tina Turner | 8 | 25 |
| Usher | 8 | 22 |
Take 6
Lauryn Hill
Blackwood Brothers | 8 | 19 |
Anita Baker
Metallica
Rick Rubin | 8 | 18 |
Eddie Palmieri
Ziggy Marley | 8 | 14 |
Los Togres del Norte
The Manhattan Transfer | 8 | 13 |
| Skrillex | 8 | 12 |
| Stephen Marley | 8 | 11 |
| Prince | 7 | 38 |
| Kendrick Lamar | 7 | 29 |
| Madonna | 7 | 28 |
| will.i.am | 7 | 26 |
| Robert Frost | 7 | 21 |
| John Mayer | 7 | 19 |
| Carrie Underwood | 7 | 14 |
| Lady Antebellum | 7 | 13 |
Simon & Garfunkel
Ricky Skaggs and Kentucky Thunder | 7 | 11 |
| Whitney Houston | 6 | 25 |
| Robert M. Jones | 6 | 23 |
| Lady Gaga | 6 | 19 |
| Eagles | 6 | 18 |
| Israel Houghton | 6 | 16 |
| Black Eyed Peas | 6 | 15 |
| Tito Puente | 6 | 12 |
| Mariah Carey | 5 | 34 |
| Janet Jackson | 5 | 26 |
| Billy Joel | 5 | 23 |
Christina Aguilera
Donna Summer
James Taylor
Cee Lo Green | 5 | 18 |
| Mary Chapin Carpenter | 5 | 17 |
| Peter, Paul & Mary | 5 | 16 |
Dionne Warwick
Michael McDonald | 5 | 14 |
Jay Newland
Maria Schneider | 5 | 12 |
Lady Antebellum
Kuk Harrell | 5 | 10 |
| Christopher Cross | 5 | 9 |
Dave Russell
Flaco Jimenez
Ward Swingle | 5 | 8 |
| India.arie | 4 | 22 |
| Timbaland | 4 | 21 |
| Erykah Badu | 4 | 19 |
Yolanda Adams
Tracy Chapman | 4 | 13 |
Marvin Hamlisch
Lisa Lopes | 4 | 12 |
| Lenny Kravitz | 4 | 9 |
Robert Spano
Carole King | 4 | 8 |
Pepe Aguilar
Lyle Lovett | 4 | 7 |
| Drake | 3 | 35 |
Pink
T.I | 3 | 19 |
| Gwen Stefani | 3 | 18 |
| Etta James | 3 | 17 |
Elvis Presley
Kelly Clarkson
Harry Connick Jr. | 3 | 14 |
Clare Fischer
Puff Daddy
Bill Holman | 3 | 13 |
Gloria Estefan
Maroon 5
Red Hot Chili Peppers | 3 | 12 |
Los Lobos
Vikki Carr | 3 | 11 |
Rob Thomas
Shawn Colvin | 3 | 10 |
| Steely Dan | 3 | 9 |
| James Brown | 3 | 8 |
| The Carpenters | 3 | 7 |
Bob Newhart
Esperanza Spalding
Toto | 3 | 5 |
Lin-Manuel Miranda
Tim Martyn | 3 | 4 |
| Lenny White | 3 | 3 |
Cyndi Lauper
Miranda Lambert | 2 | 16 |
| Melissa Etheridge | 2 | 15 |
| Patti LaBelle | 2 | 13 |
| Marvin Gaye | 2 | 12 |
| Yehudi Menuhin | 2 | 10 |
Intocable
No Doubt
Jimmy Carter
Brian Wilson | 2 | 9 |
Marc Anthony
Peter Nero
Nate Ruess | 2 | 8 |
La Mafia
LeAnn Rimes
Brave Combo
Fleetwood Mac | 2 | 7 |
Jennifer Hudson
Linkin Park | 2 | 6 |
Nate Hills
Otis Redding
Bobby Darin
Vernon Reid
Colbie Caillat | 2 | 5 |
Ted Nash
The Wreckers | 2 | 4 |
Little Joe y La Familia
Lisa Fischer | 2 | 3 |
| Judy Garland | 2 | 2 |
| Chris Brown | 1 | 16 |
50 Cent
Elvis Costello | 1 | 14 |
| Ray Barretto | 1 | 13 |
Pearl Jam
Carter Beauford | 1 | 12 |
Dave Matthews Band
Eddie Blazonczyk
Jon Bon Jovi | 1 | 11 |
Q-Tip
Chicago (band) | 1 | 10 |
David Crosby
The Neptunes
Bon Jovi | 1 | 9 |
Ashanti
Mariachi Divas
John McLaughlin Williams
Stephen Stills
Fiona Apple | 1 | 8 |
Cher
Queen Latifah
Mongo Santamaria
Paula Cole
Nat King Cole | 1 | 7 |
Stargate
Bobby Bare
Crosby, Stills & Nash | 1 | 6 |
Gloria Gaynor
Emilio Navaira
Ciara
FUN (band) | 1 | 5 |
The Chainsmokers
Steve Jordan
Pink Floyd
Michelle Branch
Frank Yankovic
Kentucky Headhunters
Monica
Imagine Dragons
Alfred Newman
Julieta Venegas | 1 | 4 |
Cal Tjader
Mariachi los Camperos
Texas Tornados
Los Palominos
Meghan Trainor
Twenty One Pilots
La Santa Cecilia
Lila Downs
The Band Perry |
1 | 3 |
Gloria Cheng
Bacilos
Los Super Seven
The Legends
Paula Abdul
Bobby Brown
Otha Nash
America | 1 | 2 |
Jesse Harris
Sirah (rapper)
Solange
St. Vincent
Stephen McLaughlin
Chente Barrera
Los Texmaniacs
Jessica Rivera
Puff Daddy & The Family
The Product G&B
Freddie Nartinez, Jr.
Daya | 1 | 1 |