Jararhagin
| Jararhagin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.73 | ||||||||
| CAS number | 160477-79-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Jararhagin (EC 3.4.24.73, HF2-proteinase, JF1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu-and -Phe24-Phe- bonds in insulin B chain
This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).
References
- ↑ Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). "Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca". In Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. pp. 111–121.
- ↑ Assakura MT, Reichl AP, Mandelbaum FR (1986). "Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)". Toxicon. 24 (9): 943–6. doi:10.1016/0041-0101(86)90094-2. PMID 3810664.
- ↑ Paine MJ, Desmond HP, Theakston RD, Crampton JM (November 1992). "Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family". The Journal of Biological Chemistry. 267 (32): 22869–76. PMID 1385408.
External links
- Jararhagin at the US National Library of Medicine Medical Subject Headings (MeSH)
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