Indolin-2-one monooxygenase

Indolin-2-one monooxygenase
Identifiers
EC number 1.14.13.138
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Indolin-2-one monooxygenase (EC 1.14.13.138, BX3 (gene), CYP71C2 (gene)) is an enzyme with systematic name indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

indolin-2-one + NAD(P)H + H+ + O2 3-hydroxyindolin-2-one + NAD(P)+ + H2O

Indolin-2-one monooxygenase is involved in the biosynthesis of protective and allelopathic benzoxazinoids in some plants.

References

  1. Frey, M.; Chomet, P.; Glawischnig, E.; Stettner, C.; Grün, S.; Winklmair, A.; Eisenreich, W.; Bacher, A.; Meeley, R.B.; Briggs, S.P.; Simcox, K.; Gierl, A. (1997). "Analysis of a chemical plant defense mechanism in grasses". Science. 277 (5326): 696–699. doi:10.1126/science.277.5326.696. PMID 9235894.
  2. Glawischnig, E.; Grun, S.; Frey, M.; Gierl, A. (1999). "Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses". Phytochemistry. 50 (6): 925–930. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.
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