IgA-specific metalloendopeptidase

IgA-specific metalloendopeptidase
Identifiers
EC number 3.4.24.13
CAS number 72231-73-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

IgA-specific metalloendopeptidase (EC 3.4.24.13, immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of Pro-Thr bond in the hinge region of the heavy chain of human immunoglobulin A

This enzyme is present in several pathogenic species of Streptococcus.

Other species, for instance bacteria that cause meningitis, gonorrhea, some cases of pneumonia, sinusitis and ear infections also produce an enzyme that cleaves IgA, but this is a serine protease and is metal-independent.[4]

References

  1. ↑ Kornfeld SJ, Plaut AG (1981). "Secretory immunity and the bacterial IgA proteases". Reviews of Infectious Diseases. 3 (3): 521–34. doi:10.1093/clinids/3.3.521. PMID 6792682.
  2. ↑ Gilbert JV, Plaut AG, Wright A (January 1991). "Analysis of the immunoglobulin A protease gene of Streptococcus sanguis". Infection and Immunity. 59 (1): 7–17. PMC 257698. PMID 1987065.
  3. ↑ Gilbert JV, Plaut AG, Fishman Y, Wright A (August 1988). "Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli". Infection and Immunity. 56 (8): 1961–6. PMC 259508. PMID 3294181.
  4. ↑ Parsons HK, Vitovski S, Sayers JR (December 2004). "Immunoglobulin A1 proteases: a structure-function update". Biochemical Society Transactions. 32 (Pt 6): 1130–2. doi:10.1042/BST0321130. PMID 15506988.
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