Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)
Identifiers
EC number 2.5.1.82
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.82, HexPS, (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase, HexPPs, hexaprenyl diphosphate synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 isopentenyl diphosphate 2 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate.

References

  1. ↑ Hemmi H, Ikejiri S, Yamashita S, Nishino T (February 2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus". Journal of Bacteriology. 184 (3): 615–20. doi:10.1128/JB.184.3.615-620.2002. PMC 139513. PMID 11790729.
  2. ↑ Hemmi H, Noike M, Nakayama T, Nishino T (October 2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations". Biochemical and Biophysical Research Communications. 297 (5): 1096–101. doi:10.1016/S0006-291X(02)02348-3. PMID 12372398.
  3. ↑ Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH (December 2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures". Journal of Bacteriology. 187 (23): 8137–48. doi:10.1128/JB.187.23.8137-8148.2005. PMC 1291270. PMID 16291686.
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