Hematoporphyrin

Hematoporphyrin
Clinical data
Routes of
administration		 Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.034.939 Edit this at Wikidata
Chemical and physical data
Formula C34H38N4O6
Molar mass 598.69 g/mol
3D model (JSmol)
Melting point 172.5 °C (342.5 °F)
  (verify)

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900.[1]

It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy.[2]

Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.[3][4]

References

  1. ↑ "SpringerLink - Journal Article".
  2. ↑ David Kessel (1984). "Hematoporphyrin and HPD: Photophysics, Photochemistry And Phototherapy". Photochemistry and Photobiology. 39: 851–859. doi:10.1111/j.1751-1097.1984.tb08871.x.
  3. ↑ O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
  4. ↑ "Hematoporphyrin as a Therapeutic Agent in the Psychoses -- Strecker et al. 90 (6): 1157 -- Am J Psychiatry".


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