Glycosyltransferase DesVII

Glycosyltransferase DesVII
Identifiers
EC number 2.4.1.277
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glycosyltransferase DesVII (EC 2.4.1.277, DesVII) is an enzyme with systematic name dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide dTDP + 10-deoxymethymycin

DesVII is the glycosyltransferase responsible for the attachment of TDP-D-desosamine to macrolactones of varied ring sizes.

References

  1. ↑ Borisova, S.A.; Liu, H.W. (2010). "Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway". Biochemistry. 49 (37): 8071–8084. doi:10.1021/bi1007657. PMC 2939310. PMID 20695498.
  2. ↑ Borisova, S.A.; Kim, H.J.; Pu, X.; Liu, H.W. (2008). "Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications". Chembiochem. 9 (10): 1554–1558. doi:10.1002/cbic.200800155. PMC 4400176. PMID 18548476.
  3. ↑ Hong, J.S.; Park, S.J.; Parajuli, N.; Park, S.R.; Koh, H.S.; Jung, W.S.; Choi, C.Y.; Yoon, Y.J. (2007). "Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation". Gene. 386 (1–2): 123–130. doi:10.1016/j.gene.2006.08.021. PMID 17049185.
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