Glycoside hydrolase family 98

Glycosyl hydrolase family 98
Identifiers
Symbol Glyco_hydro_98M
Pfam PF08306
InterPro IPR013191
CAZy GH98
Glycosyl hydrolase family 98 C-terminal domain
Identifiers
Symbol Glyco_hydro_98C
Pfam PF08307
InterPro IPR013190

In molecular biology, glycoside hydrolase family 98 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]

Members of glycoside hydrolase family 98 have endo-β-galactosidase activity. This family includes E-ABase from Clostridium perfringens which cleaves both blood group A and B glycotopes.[8]

The putative catalytic domain is found to the N-terminus of a second domain, which is not expected to form part of the catalytic activity.

References

  1. ↑ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
  2. ↑ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
  3. ↑ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 ( Pt 2) (Pt 2): 695–6. PMC 1217404. PMID 8687420.
  4. ↑ "Home". CAZy.org. Retrieved 2018-03-06.
  5. ↑ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMID 24270786.
  6. ↑ "Glycoside Hydrolase Family 98". CAZypedia.org. Retrieved 2018-03-06.
  7. ↑ "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563.
  8. ↑ Anderson KM, Ashida H, Maskos K, Dell A, Li SC, Li YT (2005). "A clostridial endo-beta-galactosidase that cleaves both blood group A and B glycotopes: the first member of a new glycoside hydrolase family, GH98". J Biol Chem. 280 (9): 7720–8. doi:10.1074/jbc.M414099200. PMID 15618227.
This article incorporates text from the public domain Pfam and InterPro: IPR013190
This article incorporates text from the public domain Pfam and InterPro: IPR013191
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