Glycoside hydrolase family 83

Hemagglutinin-neuraminidase
Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase.[1]
Identifiers
Symbol HN
Pfam PF00423
Pfam clan CL0434
InterPro IPR000665
SCOP 1usr
SUPERFAMILY 1usr

In molecular biology, glycoside hydrolase family 83 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy web site,[5][6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[7][8]

Glycoside hydrolase family 83 CAZY GH_83 includes enzymes with neuraminidase EC 3.2.1. activity.[9]

References

  1. ↑ Zaitsev V, von Itzstein M, Groves D, et al. (April 2004). "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion". J. Virol. 78 (7): 3733–41. doi:10.1128/JVI.78.7.3733-3741.2004. PMC 371092. PMID 15016893.
  2. ↑ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
  3. ↑ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
  4. ↑ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 ( Pt 2) (Pt 2): 695–6. PMC 1217404. PMID 8687420.
  5. ↑ "Home". CAZy.org. Retrieved 2018-03-06.
  6. ↑ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMID 24270786.
  7. ↑ "Glycoside Hydrolase Family 83". CAZypedia.org. Retrieved 2018-03-06.
  8. ↑ "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563.
  9. ↑ Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS (2005). "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose". Structure. 13 (5): 803–15. doi:10.1016/j.str.2005.02.019. PMID 15893670.
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