Glucuronyl-galactosyl-proteoglycan 4-a-N-acetylglucosaminyltransferase

Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Identifiers
EC number 2.4.1.223
CAS number 179241-74-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.223, alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan

This enzyme is involved in the initiation of heparin and heparan sulfate synthesis.

References

  1. ↑ Kitagawa, H.; Shimakawa, H.; Sugahara, K. (1999). "The tumor suppressor EXT-like gene EXTL2 encodes an α1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate". J. Biol. Chem. 274: 13933–13937. doi:10.1074/jbc.274.20.13933. PMID 10318803.
  2. ↑ Kitagawa, H.; Egusa, N.; Tamura, J.I.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K. (2001). "rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate". J. Biol. Chem. 276 (7): 4834–4838. doi:10.1074/jbc.C000835200. PMID 11121397.
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