Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-b-N-acetylgalactosaminyltransferase

Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Identifiers
EC number 2.4.1.175
CAS number 96189-40-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

This enzyme is involved in the biosynthesis of chondroitin sulfate.

References

  1. ↑ Rohrmann, K.; Niemann, R.; Buddecke, E. (1985). "Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate". Eur. J. Biochem. 148 (3): 463–469. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
  2. ↑ Kitagawa, H.; Uyama, T.; Sugahara, K. (2001). "Molecular cloning and expression of a human chondroitin synthase". J. Biol. Chem. 276: 38721–38726. doi:10.1074/jbc.M106871200. PMID 11514575.
  3. ↑ DeAngelis, P.L.; Padgett-McCue, A.J. (2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". J. Biol. Chem. 275: 24124–24129. doi:10.1074/jbc.M003385200. PMID 10818104.
  4. ↑ Ninomiya, T.; Sugiura, N.; Tawada, A.; Sugimoto, K.; Watanabe, H.; Kimata, K. (2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". J. Biol. Chem. 277: 21567–21575. doi:10.1074/jbc.M201719200. PMID 11943778.
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