Geranylfarnesyl diphosphate synthase

Geranylfarnesyl diphosphate synthase
Identifiers
EC number 2.5.1.81
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Geranylfarnesyl diphosphate synthase (EC 2.5.1.81, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit).[1][2][3][4] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + isopentenyl diphosphate (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate

The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.

References

  1. ↑ Ogawa, T.; Yoshimura, T.; Hemmi, H. (2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochem. Biophys. Res. Commun. 393: 16–20. doi:10.1016/j.bbrc.2010.01.063. PMID 20097171.
  2. ↑ Tachibana, A.; Yano, Y.; Otani, S.; Nomura, N.; Sako, Y.; Taniguchi, M. (2000). "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity". Eur. J. Biochem. 267: 321–328. doi:10.1046/j.1432-1327.2000.00967.x. PMID 10632701.
  3. ↑ Tachibana, A. (1994). "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Lett. 341: 291–294. doi:10.1016/0014-5793(94)80475-3. PMID 8137956.
  4. ↑ Lee, P.C.; Mijts, B.N.; Petri, R.; Watts, K.T.; Schmidt-Dannert, C. (2004). "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Eng. Des. Sel. 17: 771–777. doi:10.1093/protein/gzh089. PMID 15548566.
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