Gamma probe

A gamma probe

A gamma probe is a handheld device containing a scintillation counter, for intraoperative use following injection of a radionuclide, to locate sentinel lymph nodes by their radioactivity.[1] It is used primarily for sentinel lymph node mapping and parathyroid surgery. Gamma probes are also used for RSL (radioactive seed localization), to locate small and non-palpable breast lesions.[2][3]:243

History

The sentinel node market experienced high growth in the early and mid 90's starting with melanoma sentinel node surgical search and breast cancer sentinel node staging; both are currently considered standards of care.[4] The use of a radioactive tracer, rather than a coloured dye, was proposed in 1984.[5][6]

Clinical use

To locate the draining lymph nodes or sentinel lymph node from a breast cancer tumour a Technetium-99m based radiopharmaceutical is common. This may be a nanocolloid or sestamibi.[7] Although imaging with a gamma camera may also take place, the idea of a small gamma probe is that it can be used to identify lymph nodes (or other sites) with uptake at a much higher resolution, during an operation. The probe may be collimated to further restrict the field of detection.[8][9]

See also

References

  1. ↑ "Gamma Probe". Human Health Campus. IAEA. Retrieved 11 January 2018.
  2. ↑ Langhans, Linnea; Levin Klausen, Thomas; Filtenborg Tvedskov, Tove; Vejborg, Ilse; Kroman, Niels; Hesse, Birger (11 August 2016). "Radioguided Surgery for Localization of Nonpalpable Breast Lesions A Mini-Review". Current Radiopharmaceuticals. 9 (2): 114–120. doi:10.2174/1874471009999160625105340.
  3. ↑ Mariani, Giuliano; Giuliano, Armando E.; Strauss, H. William (2010). Radioguided Surgery. Heidelburg: Springer. ISBN 9780387383279.
  4. ↑ Mansel, Robert E. (8 July 2009). "History, Present Status and Future of Sentinel Node Biopsy in Breast Cancer: The Mary Béves Lecture". Acta Oncologica. 39 (3): 265–268. doi:10.1080/028418600750012998. PMID 10987219.
  5. ↑ Torchilin, Vladimir P. (1995). Handbook of Targeted Delivery of Imaging Agents. CRC Press. p. 242. ISBN 9780849383083.
  6. ↑ Heller, Samantha L.; Moy, Linda (2017). Breast Oncology: Techniques, Indications, and Interpretation. Springer. p. 302. ISBN 9783319425634.
  7. ↑ Schauer, Alfred; Becker, Wolfgang; Reiser, Maximilian F.; Possinger, Kurt (2005). The Sentinel Lymph Node Concept. Springer Science & Business Media. p. 28. ISBN 9783540263937.
  8. ↑ Mariani, Giuliano; Giuliano, Armando E.; Strauss, H. William (2010). Radioguided Surgery. Springer Science & Business Media. p. 22. ISBN 9780387383279.
  9. ↑ Dössel, Olaf; Schlegel, Wolfgang C. (2010). World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany: Vol. 25/III Radiation Protection and Dosimetry, Biological Effects of Radiation. Springer Science & Business Media. p. 54. ISBN 9783642039027.
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