GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase
Identifiers
EC number 2.4.1.252
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase (EC 2.4.1.252, GumH, AceA, alpha1,3-mannosyltransferase AceA) is an enzyme with systematic name GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase .[1][2][3][4][5] This enzyme catalyses the following chemical reaction

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

In the bacterium Gluconacetobacter xylinus the enzyme is involved in the biosynthesis of the exopolysaccharide acetan.

References

  1. ↑ Geremia, R.A.; Roux, M.; Ferreiro, D.U.; Dauphin-Dubois, R.; Lellouch, A.C.; Ielpi, L. (1999). "Expression and biochemical characterisation of recombinant AceA, a bacterial α-mannosyltransferase". Mol. Gen. Genet. 261 (6): 933–940. doi:10.1007/s004380051040. PMID 10485283.
  2. ↑ Abdian, P.L.; Lellouch, A.C.; Gautier, C.; Ielpi, L.; Geremia, R.A. (2000). "Identification of essential amino acids in the bacterial α-mannosyltransferase aceA". J. Biol. Chem. 275: 40568–40575. doi:10.1074/jbc.M007496200. PMID 11001941.
  3. ↑ Petroni, E.A.; Ielpi, L. (1996). "Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol α-mannosyltransferase gene from Acetobacter xylinum". J. Bacteriol. 178 (16): 4814–4821. PMC 178262. PMID 8759843.
  4. ↑ Lellouch, A.C.; Watt, G.M.; Geremia, R.A.; Flitsch, S.L. (2000). "Phytanyl-pyrophosphate-linked substrate for a bacterial α-mannosyltransferase". Biochem. Biophys. Res. Commun. 272: 290–292. doi:10.1006/bbrc.2000.2771. PMID 10872841.
  5. ↑ Katzen, F.; Ferreiro, D.U.; Oddo, C.G.; Ielmini, M.V.; Becker, A.; Puhler, A.; Ielpi, L. (1998). "Xanthomonas campestris' pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence". J. Bacteriol. 180 (7): 1607–1617. PMC 107069. PMID 9537354.
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