GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
Identifiers
EC number 2.4.1.257
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.257, GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase, Alg2 mannosyltransferase, ALG2 (gene), GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase) is an enzyme with systematic name GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol

The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor.

References

  1. ↑ Kampf, M.; Absmanner, B.; Schwarz, M.; Lehle, L. (2009). "Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis". J. Biol. Chem. 284: 11900–11912. doi:10.1074/jbc.m806416200. PMC 2673259. PMID 19282279.
  2. ↑ O'Reilly, M.K.; Zhang, G.; Imperiali, B. (2006). "In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis". Biochemistry. 45: 9593–9603. doi:10.1021/bi060878o. PMID 16878994.
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