GDP-4-dehydro-6-deoxy-D-mannose reductase

GDP-4-dehydro-6-deoxy-D-mannose reductase
Identifiers
EC number 1.1.1.281
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-mannose + NAD(P)+ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+

The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD+, and NADP+, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming). Other names in common use include GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous], GDP-6-deoxy-D-lyxo-4-hexulose reductase, and Rmd. This enzyme participates in fructose and mannose metabolism.

References

    • Messner P; Graninger, M; Adam, G; Puchberger, M; Kosma, P; Zayni, S; Messner, P (2001). "Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T". J. Biol. Chem. 276 (8): 5577&ndash, 83. doi:10.1074/jbc.M010027200. PMID 11096116.
    • Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R (2002). "Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose". Eur. J. Biochem. 269 (2): 593&ndash, 601. doi:10.1046/j.0014-2956.2001.02688.x. PMID 11856318.


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