Fragilysin

Fragilysin
Identifiers
EC number 3.4.24.74
CAS number 188596-63-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Fragilysin (EC 3.4.24.74, Bacteroides fragilis (entero)toxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Broad proteolytic specificity, bonds hydrolysed including -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly

It is thought to be a cause of diarrhoea in animals and humans.

References

  1. ↑ Moncrief, J.S.; Obiso, R.; Jr.; Barroso, L.A.; Kling, J.J.; Wright, R.L.; Van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D. (1995). "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infect. Immun. 63: 175–181. PMC 172975. PMID 7806355.
  2. ↑ Obiso, R.J.; Jr.; Lyerly, D.M.; Van Tassell, R.L.; Wilkins, T.D. (1995). "Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo". Infect. Immun. 63: 3820–3826. PMC 173537. PMID 7558286.
  3. ↑ Donelli, G.; Fabbri, A.; Fiorentini, C. (1996). "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells". Infect. Immun. 64: 113–119. PMC 173735. PMID 8557328.
  4. ↑ Koshy, S.S.; Montrose, M.H.; Sears, C.L. (1996). "Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis". Infect. Immun. 64: 5022–5028. PMC 174483. PMID 8945541.
  5. ↑ Kling, J.J.; Wright, R.L.; Moncrief, J.S.; Wilkins, T.D. (1997). "Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis". FEMS Microbiol. Lett. 146: 279–284. doi:10.1016/s0378-1097(96)00488-0. PMID 9011050.
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