Enterocyte

Enterocyte
Enterocyte
Details
Location	Small intestine
Shape	simple columnar
Function	Epithelial cells
Identifiers
Latin	enterocytus
TH	H3.04.03.0.00006
Anatomical terms of microanatomy

Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestine. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal lumen. The cells also have a secretory role.

Function

The major functions of enterocytes include:^[1]

• Ion uptake, including sodium, calcium, magnesium, iron, zinc, and copper. This typically occurs through active transport.
• Water uptake. This follows the osmotic gradient established by Na+/K+ ATPase on the basolateral surface. This can occur transcellularly or paracellularly.
• Sugar uptake. Polysaccharidases and disaccharidases in the glycocalyx break down large sugar molecules, which are then absorbed. Glucose crosses the apical membrane of the enterocyte using the sodium-glucose cotransporter. It moves through the cytosol (cytoplasm) and exits the enterocyte via the basolateral membrane (into the blood capillary) using GLUT2. Galactose uses the same transport system. Fructose, on the other hand, crosses the apical membrane of the enterocyte, using GLUT5. It is thought to cross into the blood capillary using one of the other GLUT transporters.
• Peptide and amino acid uptake. Peptidases in the glycocalyx cleave proteins to amino acids or small peptides. Enteropeptidase (also known as enterokinase) is responsible for activating pancreatic trypsinogen into trypsin, which activates other pancreatic zymogens. They are involved in the Krebs and the Cori Cycles and can be synthesized with lipase.
• Lipid uptake. Lipids are broken down by pancreatic lipase and bile, and then diffuse into the enterocytes. Smaller lipids are transported into intestinal capillaries, while larger lipids are processed by the Golgi and smooth endoplasmic reticulum into lipoprotein chylomicra and exocytozed into lacteals.
• Vitamin B12 uptake. Receptors bind to the vitamin B₁₂-gastric intrinsic factor complex and are taken into the cell.
• Resorption of unconjugated bile salts. Bile that was released and not used in emulsification of lipids are reabsorbed in the ileum. Also known as the enterohepatic circulation.
• Secretion of immunoglobulins. IgA from plasma cells in the mucosa are absorbed through receptor mediated endocytosis on the basolateral surface and released as a receptor-IgA complex into the intestinal lumen. The receptor component confers additional stability to the molecule.

Clinical significance

Dietary fructose intolerance occurs when there is a deficiency in the amount of fructose carrier.

Lactose intolerance is the most common problem of carbohydrate digestion and occurs when the human body doesn't produce a sufficient amount of lactase (a disaccharidase) enzyme to break down the sugar lactose found in dairy. As a result of this deficiency, undigested lactose is not absorbed and is instead passed on to the colon. There bacteria metabolize the lactose and in doing so release gas and metabolic products that enhance colonic motility. This causes gas and other uncomfortable symptoms.

Toxins such as cholera toxin may increase the secretion or decrease the intake of water and electrolytes, leading to possibly severe dehydration and electrolyte imbalance.^[2]

Rotavirus selectively invades and kills mature enterocytes in the small intestine.^[3]

See also

• List of human cell types derived from the germ layers

References

External links

• Histology image: 11706loa – Histology Learning System at Boston University - "Digestive System: Alimentary Canal — jejunum, goblet cells and enterocytes"