MAPK4

MAPK4
Identifiers
AliasesMAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDsMGI: 2444559 HomoloGene: 2058 GeneCards: MAPK4
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q21.1-q21.2Start50,560,078 bp[1]
End50,731,824 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5596

225724

Ensembl

ENSG00000141639
ENSG00000282110

ENSMUSG00000024558

UniProt

P31152

Q6P5G0

RefSeq (mRNA)

NM_001292039
NM_001292040
NM_002747

NM_172632
NM_001360936

RefSeq (protein)

NP_001278968
NP_001278969
NP_002738

NP_766220
NP_001347865

Location (UCSC)Chr 18: 50.56 – 50.73 MbChr 18: 73.93 – 74.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[5][6]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[6]

The Arabidopsis MAPK4 is important in signalling [7]

References

  1. 1 2 3 ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024558 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
  6. 1 2 "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
  7. ↑ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, Nielsen HB, Lacy M, Austin MJ, Parker JE, Sharma SB, Klessig DF, Martienssen R, Mattsson O, Jensen AB & Mundy J (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell. 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186.

Further reading

  • Seger R, Krebs EG (1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
  • Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
  • Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255.
  • Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Lett. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925.
  • Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359. PMID 7969157.
  • Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sun M, Wei Y, Yao L, et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
  • Kant S, Schumacher S, Singh MK, et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.


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