Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
Identifiers
EC number 2.4.1.260
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.260, ALG12, ALG12 mannosyltransferase, ALG12 alpha1,6mannosyltransferase, dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase, dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase, EBS4, Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate

References

  1. ↑ Frank CG, Aebi M (November 2005). "ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis". Glycobiology. 15 (11): 1156–63. doi:10.1093/glycob/cwj002. PMID 15987956.
  2. ↑ Hong Z, Jin H, Fitchette AC, Xia Y, Monk AM, Faye L, Li J (December 2009). "Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis". The Plant Cell. 21 (12): 3792–802. doi:10.1105/tpc.109.070284. PMC 2814505. PMID 20023196.
  3. ↑ Cipollo JF, Trimble RB (November 2002). "The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus". Glycobiology. 12 (11): 749–62. doi:10.1093/glycob/cwf082. PMID 12460943.
  4. ↑ Grubenmann CE, Frank CG, Kjaergaard S, Berger EG, Aebi M, Hennet T (September 2002). "ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg". Human Molecular Genetics. 11 (19): 2331–9. doi:10.1093/hmg/11.19.2331. PMID 12217961.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.