Diapolycopene oxygenase

Diapolycopene oxygenase
Identifiers
EC number 1.14.99.44
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Diapolycopene oxygenase (EC 1.14.99.44, crtP) is an enzyme with systematic name 4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

4,4'-diapolycopene + 4 AH2 + 4 O2 4,4'-diapolycopenedial + 4 A + 6 H2O

Diapolycopene oxygenase is involved in the biosynthesis of C30 carotenoids such as staphyloxanthin.

References

  1. Mijts, B.N.; Lee, P.C.; Schmidt-Dannert, C. (2005). "Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution". Chem. Biol. 12 (4): 453–460. doi:10.1016/j.chembiol.2005.02.010. PMID 15850982.
  2. Tao, L.; Schenzle, A.; Odom, J.M.; Cheng, Q. (2005). "Novel carotenoid oxidase involved in biosynthesis of 4,4-diapolycopene dialdehyde". Appl. Environ. Microbiol. 71 (6): 3294–3301. doi:10.1128/AEM.71.6.3294-3301.2005. PMC 1151855. PMID 15933032.


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