Desosaminyl transferase EryCIII

Desosaminyl transferase EryCIII
Identifiers
EC number 2.4.1.278
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Desosaminyl transferase EryCIII (EC 2.4.1.278, EryCIII) is an enzyme with systematic name dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B dTDP + erythromycin D

The enzyme is involved in erythromycin biosynthesis.

References

  1. ↑ Yuan, Y.; Chung, H.S.; Leimkuhler, C.; Walsh, C.T.; Kahne, D.; Walker, S. (2005). "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". J. Am. Chem. Soc. 127 (41): 14128–14129. doi:10.1021/ja053704n. PMC 2525786. PMID 16218575.
  2. ↑ Lee, H.Y.; Chung, H.S.; Hang, C.; Khosla, C.; Walsh, C.T.; Kahne, D.; Walker, S. (2004). "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". J. Am. Chem. Soc. 126 (32): 9924–9925. doi:10.1021/ja048836f. PMID 15303858.
  3. ↑ Moncrieffe, M.C.; Fernandez, M.J.; Spiteller, D.; Matsumura, H.; Gay, N.J.; Luisi, B.F.; Leadlay, P.F. (2012). "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". J. Mol. Biol. 415 (1): 92–101. doi:10.1016/j.jmb.2011.10.036. PMC 3391682. PMID 22056329.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.