D-alanine—D-serine ligase

D-alanine—D-serine ligase
Identifiers
EC number 6.3.2.35
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

D-alanine—D-serine ligase (EC 6.3.2.35, VanC, VanE, VanG) is an enzyme with systematic name D-alanine:D-serine ligase (ADP-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

D-alanine + D-serine + ATP D-alanyl-D-serine + ADP + phosphate

The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.

References

  1. ↑ Dutka-Malen S, Molinas C, Arthur M, Courvalin P (March 1992). "Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance". Gene. 112 (1): 53–8. doi:10.1016/0378-1119(92)90302-6. PMID 1551598.
  2. ↑ Park IS, Lin CH, Walsh CT (September 1997). "Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10040–4. doi:10.1073/pnas.94.19.10040. PMC 23297. PMID 9294159.
  3. ↑ Fines M, Perichon B, Reynolds P, Sahm DF, Courvalin P (September 1999). "VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405". Antimicrobial Agents and Chemotherapy. 43 (9): 2161–4. PMC 89440. PMID 10471558.
  4. ↑ Depardieu F, Bonora MG, Reynolds PE, Courvalin P (November 2003). "The vanG glycopeptide resistance operon from Enterococcus faecalis revisited". Molecular Microbiology. 50 (3): 931–48. doi:10.1046/j.1365-2958.2003.03737.x. PMID 14617152.
  5. ↑ Watanabe S, Kobayashi N, Quiñones D, Hayakawa S, Nagashima S, Uehara N, Watanabe N (March 2009). "Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus". Microbial Drug Resistance. 15 (1): 1–9. doi:10.1089/mdr.2009.0856. PMID 19216682.
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