Cefditoren

Cefditoren
Clinical data
Trade names	Spectracef
AHFS/Drugs.com	Monograph
MedlinePlus	a605003
ATC code	J01DD16 (WHO) ;
Identifiers
	IUPAC name (7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	104145-95-1 ;
PubChem CID	9870843;
DrugBank	DB01066 ;
ChemSpider	8046534 ;
UNII	81QS09V3YW;
KEGG	D07639 ;
ChEBI	CHEBI:59343 ;
ChEMBL	CHEMBL610374 ;
ECHA InfoCard	100.214.754
Chemical and physical data
Formula	C19H18N6O5S3
Molar mass	506.58 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C3N2/C(=C(/C=C\c1scnc1C)CS[C@@H]2[C@@H]3NC(=O)C(=N\OC)/c4nc(sc4)N)C(=O)O;
	InChI InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1 ; Key:KMIPKYQIOVAHOP-YLGJWRNMSA-N ;
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Cefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Vansen Pharma Inc.

Cefditoren is also marketed under the name Meiact by Meiji Seika Pharma Co., Ltd.^[1]

Spectrum of bacterial susceptibility

Cefditoren pivoxil has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract, including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.

Haemophilus influenzae: ≥0.063 - 0.25 μg/ml
Staphylcoccus aureus: 0.25 - >128 μg/ml (includes MRSA)
Streptococcus pyogenes: ≤0.004 - 2 μg/ml^[2]

Cefditoren is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, but does not have antibacterial activity against Pseudomonas aeruginosa.^[3]

Clinical use

Indications

Cefditoren pivoxil is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, pharyngitis, and tonsillitis.

Formulations

Cefditoren pivoxil is the active ingredient in Spectracef and is available as 200- and 400-mg tablets. Cefditoren pivoxil is a prodrug which is metabolized in the body to release cefditoren as the active metabolite.

Chemical structure of cefditoren pivoxil

References

↑ Meiact Full Description Archived 2010-09-17 at the Wayback Machine.
↑ http://www.toku-e.com/Assets/MIC/Cefditoren%20sodium.pdf
↑ "Disease relevance of Cefditoren". Retrieved June 24, 2014.

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/21-222_Spectracef.cfm

External links

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Meiact Full Description Archived 2010-09-17 at the Wayback Machine.

[2] ttp://www.toku-e.com/Assets/MIC/Cefditoren%20sodium.pdf

[3] "Disease relevance of Cefditoren". Retrieved June 24, 2014.