Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12),[5] is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.[6]
Gene and Transcript
In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3.[7] It is located on chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids.[8][9]
Protein
The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1-226 on the main transcript.[10] The molecular weight of C6orf62 is 27.1 kDa and its isoelectric point is at a pH of 9.24.[11] It is located subcellularly localized throughout the cytosol.[6]
Homology
C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.
Orthologs in Select Mammals[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Pongo |
abelii |
Sumatran Orangutan |
15.2 |
NP_001126883.1 |
232 |
99 |
99 |
Ictidomys |
tridecemlineatus |
Ground Squirrel |
88 |
XP_005337081.1 |
231 |
99 |
98 |
Tupaia |
chinensis |
Treeshrew |
85 |
XP_006162754.1 |
267 |
84 |
98 |
Rattus |
norvegicus |
Brown Rat |
88 |
NP_001017510.1 |
232 |
99 |
98 |
Orthologs in Select Ray-Finned Fish[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Salmo |
salar |
Salmon |
435 |
XP_014034327.1 |
233 |
82 |
93 |
Sinocyclocheilus |
rhinoceros |
Golden-lined Barbell |
435 |
XP_016388718.1 |
230 |
87 |
94 |
Hippocampus |
comes |
Seahorse |
435 |
XP_019729847.1 |
234 |
80 |
91 |
Orthologs in Select Amphibians[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Nanorana |
parkeri |
High Himalaya Frog |
353 |
XP_018411819.1 |
232 |
95 |
97 |
Xenopus |
trpocalis |
African Clawed Frog |
353 |
NP_001120278.1 |
232 |
93 |
98 |
Orthologs in Select Reptiles[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Chrysemys |
picta belli |
Painted Turtle |
320 |
XP_005281462.1 |
233 |
97 |
98 |
Python |
vbivittatus |
Burmese Python |
320 |
XP_007521998.1 |
233 |
96 |
99 |
Chelonia |
mydas |
Green Sea Turtle |
320 |
XP_007060449.1 |
231 |
97 |
98 |
Alligator |
sinensis |
Chinese Alligator |
320 |
XP_006034488.1 |
232 |
98 |
99 |
Orthologs in Select Birds[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Tauraco |
erythrolophus |
Red-crested Tauraco |
320 |
XP_009991398.1 |
232 |
97 |
|
Taeniopygia |
guttata |
Zebra Finch |
320 |
XP_002194166.1 |
232 |
98 |
|
Manacus |
vitellinus |
Gold Marked Manakin |
320 |
XP_017925511.1 |
241 |
98 |
|
Orthologs in Select Invertebrates[15]
Genus |
Species |
Common Name |
Date of divergence (MYA) |
RefSeq |
AA Length |
% Identity |
% Similarity |
Ciona |
intestinalis |
Sea Squirt |
677 |
XP_002119736.1 |
233 |
38 |
62 |
Crassostrea |
gigas |
Pacific Oyster |
758 |
XP_011438527.1 |
231 |
62 |
80 |
Hellobdella |
robusta |
Glossiphoniidae Leech |
758 |
XP_009016977.1 |
264 |
35 |
51 |
Octopus |
bimaculoides |
Two-Spot Octopus |
758 |
XP_014780369.1 |
197 |
60 |
79 |
Saccoglossus |
kowalevskii |
Acorn Worm |
627 |
XP_002741666.1 |
230 |
66 |
83 |
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000112308 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019132 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Database, GeneCards Human Gene. "C6orf62 Gene - GeneCards | CF062 Protein | CF062 Antibody". www.genecards.org. Retrieved 2017-02-21.
- 1 2 "Tissue expression of C6orf62 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-05-08.
- ↑ Kent, WJ; Sugnet, CW; Furey, TS; Roskin, KM; Pringle, TH; Zahler, AM; Haussler, D (2002). "UCSC Genome Browser". UCSC Genome Browser. Retrieved 2017-02-20.
- ↑ "PREDICTED: uncharacterized protein C6orf62 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ↑ "PREDICTED: uncharacterized protein C6orf62 isoform X2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ↑ "C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ↑ Volker, Brendel (2006). "SAPS - SDSC Bio Workbench". SDSC Biology Workbench. Retrieved 2017-05-01.
- 1 2 Lab, Mike Tyers. "C6orf62 (RP1-30M3.4) Result Summary | BioGRID". thebiogrid.org. Retrieved 2017-05-08.
- ↑ "1 binary interaction found for search term C6orf62". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.
- ↑ "C6orf62 protein abundance in PaxDb". pax-db.org. Retrieved 2017-05-08.
- 1 2 3 4 5 6 "NCBI - Basic Local Alignment Search Tool". NCBI.