Biotin-independent malonate decarboxylase

Biotin-independent malonate decarboxylase
Identifiers
EC number 4.1.1.88
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Biotin-independent malonate decarboxylase (EC 4.1.1.88, malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

malonate + H+ acetate + CO2

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References

  1. ↑ Schmid, M.; Berg, M.; Hilbi, H.; Dimroth, P. (1996). "Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group". Eur. J. Biochem. 237: 221–228. doi:10.1111/j.1432-1033.1996.0221n.x. PMID 8620876.
  2. ↑ Byun, H.S.; Kim, Y.S. (1997). "Subunit organization of bacterial malonate decarboxylases: the smallest δ subunit as an acyl-carrier protein". J. Biochem. Mol. Biol. 30: 132–137.
  3. ↑ Hoenke, S.; Schmid, M.; Dimroth, P. (1997). "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli". Eur. J. Biochem. 246: 530–538. doi:10.1111/j.1432-1033.1997.00530.x. PMID 9208947.
  4. ↑ Chohnan, S.; Fujio, T.; Takaki, T.; Yonekura, M.; Nishihara, H.; Takamura, Y. (1998). "Malonate decarboxylase of Pseudomonas putida is composed of five subunits". FEMS Microbiol. Lett. 169: 37–43. doi:10.1111/j.1574-6968.1998.tb13296.x. PMID 9851033.
  5. ↑ Hoenke, S.; Schmid, M.; Dimroth, P. (2000). "Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases". Biochemistry. 39: 13233–13240. doi:10.1021/bi001154u. PMID 11052676.
  6. ↑ Handa, S.; Koo, J.H.; Kim, Y.S.; Floss, H.G. (1999). "Stereochemical course of biotin-independent malonate decarboxylase catalysis". Arch. Biochem. Biophys. 370: 93–96. doi:10.1006/abbi.1999.1369. PMID 10496981.
  7. ↑ Koo, J.H.; Kim, Y.S. (1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". Eur. J. Biochem. 266: 683–690. doi:10.1046/j.1432-1327.1999.00924.x. PMID 10561613.
  8. ↑ Kim, Y.S. (2002). "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". J. Biochem. Mol. Biol. 35: 443–451. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084.
  9. ↑ Dimroth, P.; Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.
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