Avram Hershko

Avram Hershko
Born Herskó Ferenc
(1937-12-31) 31 December 1937
Karcag, Hungary
Nationality Israel Switzerland
Known for ubiquitin-mediated protein degradation
Spouse(s)
Judith Leibowitz (m. 1963)
Children 3
Awards Nobel Prize in Chemistry (2004)
Scientific career
Fields Chemistry

Avram Hershko (Hebrew: אברהם הרשקו‎; born 31 December 1937) is a Hungarian-born Israeli biochemist and Nobel laureate in Chemistry.

Biography

Hershko was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana Margit and Moshe Hershko, both teachers.[1] Hershko emigrated to Israel in 1950. He received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

His contributions to science directly helped cure one of his long-time friends of cancer. [2]

Honours and awards

Publications

  • Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, 1783–1786.
  • Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206–8214.
  • Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619–1623.
  • Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
  • Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
  • Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–198.

Involvement with biotechnology

Professor Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.

See also

References

  1. ↑ https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/hershko-autobio.html
  2. ↑ Friedman, Sally (September 13, 2011). "Nobel Prize winner's discovery helps save longtime physician friend". Burlington County Times. phillyBurbs.com. Archived from the original on September 13, 2012. Retrieved May 15, 2012.
  3. ↑ "Israel Prize Official Site – Recipients in 1994 (in Hebrew)". Archived from the original on 2008-12-27.
  4. ↑ Wolf Prize Recipients in Medicine Archived February 26, 2009, at the Wayback Machine.
  5. ↑ Nobel citation
  6. ↑ Avram Hershko & Aaron Ciechanover, 2004 Nobel in Chemistry Archived December 19, 2005, at the Wayback Machine. – A web article
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.