Artemisinic aldehyde Delta11(13)-reductase
| Artemisinic aldehyde Delta11(13)-reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.92 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Artemisinic aldehyde Delta11(13)-reductase (EC 1.3.1.92, Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- (11R)-dihydroartemisinic aldehyde + NADP+ artemisinic aldehyde + NADPH + H+
This enzyme i present in Artemisia annua.
References
- ↑ Bertea, C.M.; Freije, J.R.; van der Woude, H.; Verstappen, F.W.; Perk, L.; Marquez, V.; De Kraker, J.W.; Posthumus, M.A.; Jansen, B.J.; de Groot, A.; Franssen, M.C.; Bouwmeester, H.J. (2005). "Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua". Planta Med. 71 (1): 40–47. doi:10.1055/s-2005-837749. PMID 15678372.
- ↑ Zhang, Y.; Teoh, K.H.; Reed, D.W.; Maes, L.; Goossens, A.; Olson, D.J.; Ross, A.R.; Covello, P.S. (2008). "The molecular cloning of artemisinic aldehyde Δ11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua". J. Biol. Chem. 283 (31): 21501–21508. doi:10.1074/jbc.M803090200. PMID 18495659.
External links
- Artemisinic+aldehyde+Delta11(13)-reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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