SRD5A3

SRD5A3
Identifiers
AliasesSRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
External IDsMGI: 1930252 HomoloGene: 41385 GeneCards: SRD5A3
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q12Start55,346,109 bp[1]
End55,373,096 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

79644

57357

Ensembl

ENSG00000128039

ENSMUSG00000029233

UniProt

Q9H8P0

Q9WUP4

RefSeq (mRNA)

NM_024592

NM_020611

RefSeq (protein)

NP_078868

NP_065636

Location (UCSC)Chr 4: 55.35 – 55.37 MbChr 5: 76.14 – 76.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.[5][6] It is one of three forms of 5α-reductase.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128039 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029233 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: steroid 5 alpha-reductase 3".
  6. ↑ Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Sci. 99 (1): 81–6. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282.

Further reading

  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cantagrel V, Lefeber DJ, Ng BG, et al. (2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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