Arabinofuranan 3-O-arabinosyltransferase

Arabinofuranan 3-O-arabinosyltransferase
Identifiers
EC number 2.4.2.47
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Arabinofuranan 3-O-arabinosyltransferase (EC 2.4.2.47, AftC) is an enzyme with systematic name alpha-(1->5)-arabinofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 3-O-alpha-D-arabinofuranosyltransferase.[1][2] This enzyme catalyses the following chemical reaction:

Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain

This enzyme is isolated from Mycobacterium smegmatis.

References

  1. ↑ Birch, H.L.; Alderwick, L.J.; Bhatt, A.; Rittmann, D.; Krumbach, K.; Singh, A.; Bai, Y.; Lowary, T.L.; Eggeling, L.; Besra, G.S. (2008). "Biosynthesis of mycobacterial arabinogalactan: identification of a novel α(1-→3) arabinofuranosyltransferase". Mol. Microbiol. 69 (5): 1191–1206. doi:10.1111/j.1365-2958.2008.06354.x. PMC 2610374. PMID 18627460.
  2. ↑ Zhang, J.; Angala, S.K.; Pramanik, P.K.; Li, K.; Crick, D.C.; Liav, A.; Jozwiak, A.; Swiezewska, E.; Jackson, M.; Chatterjee, D. (2011). "Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors". ACS Chem. Biol. 6 (8): 819–828. doi:10.1021/cb200091m. PMC 3158817. PMID 21595486.
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