Aceprometazine

Aceprometazine
Clinical data
Pregnancy; category	Contraindicated; Passes into breast milk;
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal and fecal
Identifiers
	IUPAC name 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone;
CAS Number	13461-01-3 ;
PubChem CID	26035;
DrugBank	DB01615 ;
ChemSpider	24249 ;
UNII	984N9YTM4Y;
ChEBI	CHEBI:53770 ;
ChEMBL	CHEMBL2104054;
ECHA InfoCard	100.033.315
Chemical and physical data
Formula	C19H22N2OS
Molar mass	326.456 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(c2cc1N(c3c(Sc1cc2)cccc3)CC(N(C)C)C)C;
	InChI InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3 ; Key:XLOQNFNTQIRSOX-UHFFFAOYSA-N ;
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Aceprometazine (INN) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

References

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Clinical data

Pregnancy category	Contraindicated Passes into breast milk
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal and fecal
Identifiers
IUPAC name 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
CAS Number	13461-01-3^Y
PubChem CID	26035
DrugBank	DB01615^Y
ChemSpider	24249^Y
UNII	984N9YTM4Y
ChEBI	CHEBI:53770^Y
ChEMBL	CHEMBL2104054
ECHA InfoCard	100.033.315
Chemical and physical data
Formula	C₁₉H₂₂N₂OS
Molar mass	326.456 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(c2cc1N(c3c(Sc1cc2)cccc3)CC(N(C)C)C)C
InChI InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3^Y Key:XLOQNFNTQIRSOX-UHFFFAOYSA-N^Y
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