ACP-SH:acetate ligase

ACP-SH:acetate ligase
Identifiers
EC number 6.2.1.35
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

ACP-SH:acetate ligase (EC 6.2.1.35, HS-acyl-carrier protein:acetate ligase, [acyl-carrier protein]:acetate ligase, MadH) is an enzyme with systematic name acetate:(acyl-carrier-protein) ligase (AMP-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

ATP + acetate + an [acyl-carrier protein] AMP + diphosphate + an acetyl-[acyl-carrier protein]

This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase.

References

  1. ↑ Hilbi, H.; Dehning, I.; Schink, B.; Dimroth, P. (1992). "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme". Eur. J. Biochem. 207: 117–123. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643.
  2. ↑ Berg, M.; Hilbi, H.; Dimroth, P. (1996). "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group". Biochemistry. 35: 4689–4696. doi:10.1021/bi952873p. PMID 8664258.
  3. ↑ Berg, M.; Hilbi, H.; Dimroth, P. (1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". Eur. J. Biochem. 245: 103–115. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
  4. ↑ Dimroth, P.; Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.
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