7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
| 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.77 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 2.5.1.77, FO synthase) is an enzyme with systematic name 5-amino-6-(D-ribitylamino)uracil:4-hydroxyphenylpyruvate, 4-methylphenol transferase.[1][2] This enzyme catalyses the following chemical reaction
- 5-amino-6-(D-ribitylamino)uracil + 3-(4-hydroxyphenyl)pyruvate + 2 S-adenosyl-L-methionine + H2O 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 L-methionine + 2 5'-deoxyadenosine + oxalate + NH3
This enzyme binds a 4Fe-4S cluster.
References
- ↑ Graham, D.E.; Xu, H.; White, R.H. (2003). "Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F420 biosynthesis". Arch. Microbiol. 180 (6): 455–464. doi:10.1007/s00203-003-0614-8. PMID 14593448.
- ↑ Choi, K.P.; Kendrick, N.; Daniels, L. (2002). "Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F420 and FO biosynthesis". J. Bacteriol. 184 (9): 2420–2428. doi:10.1128/JB.184.9.2420-2428.2002. PMC 134996. PMID 11948155.
External links
- 7,8-didemethyl-8-hydroxy-5-deazariboflavin+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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