6'''-Hydroxyneomycin C oxidase
| 6'''-hydroxyneomycin C oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.3.44 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
6'''-hydroxyneomycin C oxidase (EC 1.1.3.44, neoG (gene)) is an enzyme with systematic name 6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- 6'''-deamino-6'''-hydroxyneomycin C + O2 6'''-deamino-6'''-oxoneomycin C + H2O2
This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family.
References
- ↑ Huang, F.; Spiteller, D.; Koorbanally, N.A.; Li, Y.; Llewellyn, N.M.; Spencer, J.B. (2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8: 283–288. doi:10.1002/cbic.200600371. PMID 17206729.
- ↑ Clausnitzer, D.; Piepersberg, W.; Wehmeier, U.F. (2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin". J. Appl. Microbiol. 111: 642–651. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223.
External links
- -hydroxyneomycin%20C%20oxidase 6-hydroxyneomycin+C+oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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