3-hydroxyindolin-2-one monooxygenase

3-hydroxyindolin-2-one monooxygenase
Identifiers
EC number 1.14.13.139
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-hydroxyindolin-2-one monooxygenase (EC 1.14.13.139, BX4 (gene), CYP71C1 (gene)) is an enzyme with systematic name 3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming).[1][2][3] This enzyme catalyses the following chemical reaction

3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O

3-hydroxyindolin-2-one monooxygenase is involved in the biosynthesis of protective and allelopathic benzoxazinoids in some plants.

References

  1. ↑ Glawischnig, E.; Grun, S.; Frey, M.; Gierl, A. (1999). "Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses". Phytochemistry. 50 (6): 925–930. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.
  2. ↑ Frey, M.; Chomet, P.; Glawischnig, E.; Stettner, C.; Grün, S.; Winklmair, A.; Eisenreich, W.; Bacher, A.; Meeley, R.B.; Briggs, S.P.; Simcox, K.; Gierl, A. (1997). "Analysis of a chemical plant defense mechanism in grasses". Science. 277 (5326): 696–699. doi:10.1126/science.277.5326.696. PMID 9235894.
  3. ↑ Spiteller, P.; Glawischnig, E.; Gierl, A.; Steglich, W. (2001). "Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays". Phytochemistry. 57 (3): 373–376. doi:10.1016/s0031-9422(01)00037-1. PMID 11393516.
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