3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
Identifiers
EC number 1.3.1.87
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase (EC 1.3.1.87, hcaB (gene), cis-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase) is an enzyme with systematic name 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+

This enzyme catalyses a step in indegradation of phenylpropanoid compounds.

References

  1. ↑ Díaz, E.; Ferrández , A.; García JL. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–2923. PMC 107259. PMID 9603882.
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