3-(3-hydroxyphenyl)propanoate hydroxylase

3-(3-hydroxyphenyl)propanoate hydroxylase
Identifiers
EC number 1.14.13.127
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-(3-hydroxyphenyl)propanoate hydroxylase (EC 1.14.13.127, mhpA (gene)) is an enzyme with systematic name 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
(2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+

3-(3-hydroxyphenyl)propanoate hydroxylase is a flavoprotein (FAD).

References

  1. ↑ Burlingame, R.; Chapman, P.J. (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–121. PMC 217659. PMID 6345502.
  2. ↑ Burlingame, R.P.; Wyman, L.; Chapman, P.J. (1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". J. Bacteriol. 168 (1): 55–64. PMC 213419. PMID 3531186.
  3. ↑ Ferrández, A.; Garciá, J.L.; Díaz, E. (1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". J. Bacteriol. 179 (8): 2573–2581. PMC 179006. PMID 9098055.
  4. ↑ Díaz, E.; Ferrández, A.; García, J.L. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–2923. PMC 107259. PMID 9603882.
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