2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Identifiers
EC number 1.1.1.302
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, MjaRED, MJ0671 (gene)) is an enzyme with systematic name 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+

The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH functions equally well as a reductant.

References

  1. ↑ Graupner, M.; Xu, H.; White, R.H. (2002). "The pyrimidine nucleotide reductase step in riboflavin and F420 biosynthesis in archaea proceeds by the eukaryotic route to riboflavin". J. Bacteriol. 184 (7): 1952–1957. doi:10.1128/JB.184.7.1952-1957.2002. PMC 134922. PMID 11889103.
  2. ↑ Chatwell, L.; Krojer, T.; Fidler, A.; Romisch, W.; Eisenreich, W.; Bacher, A.; Huber, R.; Fischer, M. (2006). "Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase of Methanocaldococcus jannaschii". J. Mol. Biol. 359 (5): 1334–1351. doi:10.1016/j.jmb.2006.04.045. PMID 16730025.


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